17 runes

Name▲	Effect	Location
Abyssal	Gain 20% more luck during the night. Darkness increases 50% slower.	In the Abyssal Depth Maze, the other area before heading to the location to get the pan.
Annihilation I	Automatically destroy common and uncommon ores when panning.	In the tunnel from Deeproot Spring to Enchanted Ruins.
Annihilation II	Automatically destroy rare and epic ores when panning.	Located at the far back right of Fungal Marsh, surrounded by red crystals.
Critical I	Digging has a 20% chance to have 2x strength.	Inside the Merchant hut in Sunset Beach.
Critical II	Digging has a 20% chance to have 2x strength.	Inside one of the huts near the Ranger on Caldera Island.
Discovery	Chance of obtaining undiscovered ores is increased by 50%.	Inside the Maze under the Windswept Beach Lighthouse, just at the entrance past the podium/pedestal.
Equalizer	Your dig speed and shake speed are equalized to their average.	Inside the hut behind Old Prospector in Fortune River Delta.
Eternity	Your totem timers decrease 20% slower.	Found in the Timelocked Sanctuary.
Explorer	When collecting geodes, gain a 20% chance to collect another geode.	On top of the Stone Mountain in Fortune River Delta.
Misfortune	Luck is reduced to 100. Convenient for farming for quests?	In front of a tree in the line of site of the Swamp Man in Rotwood Swamp.
Mountain Climber	Gain 3 walkspeed.	Past the bridge in the first area of Snowy Mountain, keep going straight until you see an arch in the distance. You'll find the rune down below.
Purity	+1x Luck multiplier, BUT MODIFIERS CAN NO LONGER BE OBTAINED.	Received upon completing the Botanist quest.
Solitude	+20% Luck, but lose 10% Luck for every other player within 50 studs.	Below the rocks near the Lighthouse in Windswept Beach.
Speed I	Gain 2 walkspeed.	In Rubble Creek, behind the rock (behind the statue).
Summit Seeker	Gain 5% dig and shake speed for every 1% bonus walkspeed.	In front of the entrance in Frozen Peak.
Sunblessed	Gain 20% more luck in the sunlight.	Inside the area behind the waterfall/locked door in Crystal Caverns.
Volcanic	Ores with the scorched modifier gain 25% size.	On top of the Volcano. (You need to spam jump, or complete the Flame Priest quest, as lava deals damage)